“Beneficial effects of Psidium guajava leaf extract on diabetic myocardium,” an article Published in Experimental and Toxicologic Pathology.
This article – which was especially technical – discusses guava leaf as having beneficial effects on diabetic myocardium, a cardiac complication stemming from diabetes. The authors state “the aim of the present study was to evaluate the antiglycative as well as cardioprotective role of P. guajava extract in diabetic animal models” (91). A serum protein as cardiac isoform α-2 macroglobulin (cardiac α-2M) was suggested to be involved in the development of cardiac hypertrophy in rats.
“Diabetic complications often arise “as a result of non-enzymatic protein glycation which leads to the formation of advanced glycation end products (AGE’s). The non-enzymatic condensation reaction between the reducing sugars, such as glucose and the amino side chains in proteins (also called Maillard reaction or glycation) has been shown to play an important role in the development of chronic complications of diabetes mellitus” (91). Since guava leaves have been shown to help combat the formation of AGE’s, they thought they would see if a guava leaf extract would help keep the rats who had diabetes from forming these cardiovascular complications.
Using rats as models, the scientists induced diabetes by a “single intraperitoneal (body cavity) injection of STZ (strdissolved in citrate buffer…for three days (92). After the three day period, only rats with fasting blood glucose level above 200mg/dl were considered diabetic and included in the diabetic model.
As the abstract states: “Daily administration of the extract for a period of one month significantly decreased the blood glucose, glycated hemoglobin and fructosamine levels in a dose dependent manner, and the authors conclude that “These findings support that the administration of PGEt [guava leaf extract] extract may be beneficial for preventing cardiovascular complications associated with diabetes.”